Synthesis of (+)-nocardione A--use of formal radical cyclization onto a benzene ring.
- Juglone (7) was converted into enone 13; this underwent radical cyclization to afford 15, which was aromatized to 16 and elaborated into (+)-nocardione A (1), the enantiomer of the naturally-occurring tyrosine phosphatase inhibitor (-)-nocardione A (2).
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