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Pleiotropic impacts of macrophage and microglial deficiency on development in rats with targeted mutation of the Csf1r locus

Abstract:

We have produced Csf1r-deficient rats by homologous recombination in embryonic stem cells. Consistent with the role of Csf1r in macrophage differentiation, there was a loss of peripheral blood monocytes, microglia in the brain, epidermal Langerhans cells, splenic marginal zone macrophages, bone-associated macrophages and osteoclasts, and peritoneal macrophages. Macrophages of splenic red pulp, liver, lung, and gut were less affected. The pleiotropic impacts of the loss of macrophages on devel...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.4049/jimmunol.1701783

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Role:
Author
ORCID:
0000-0001-9423-557X
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Role:
Author
ORCID:
0000-0003-0949-9963
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Role:
Author
ORCID:
0000-0001-8323-5013
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Role:
Author
ORCID:
0000-0003-3131-9834
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Publisher:
American Association of Immunologists Publisher's website
Journal:
Journal of Immunology Journal website
Volume:
201
Issue:
9
Pages:
2683-2699
Publication date:
2018-11-01
Acceptance date:
2018-08-20
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Pubs id:
pubs:923863
URN:
uri:9a0db852-f79e-475d-81dc-6ba2cd7ac4ce
UUID:
uuid:9a0db852-f79e-475d-81dc-6ba2cd7ac4ce
Local pid:
pubs:923863
Language:
English
Keywords:

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