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A randomized trial of prolonged co-trimoxazole in HIV-infected children in Africa.

Abstract:

BACKGROUND: Co-trimoxazole (fixed-dose trimethoprim-sulfamethoxazole) prophylaxis administered before antiretroviral therapy (ART) reduces morbidity in children infected with the human immunodeficiency virus (HIV). We investigated whether children and adolescents receiving long-term ART in sub-Saharan Africa could discontinue co-trimoxazole. METHODS: We conducted a randomized, noninferiority trial of stopping versus continuing daily open-label co-trimoxazole in children and adolescents in Uga...

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Publication status:
Published

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Publisher copy:
10.1056/nejmoa1214901

Authors


Bwakura-Dangarembizi, M More by this author
Kendall, L More by this author
Bakeera-Kitaka, S More by this author
Nahirya-Ntege, P More by this author
Keishanyu, R More by this author
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Journal:
The New England journal of medicine
Volume:
370
Issue:
1
Pages:
41-53
Publication date:
2014-01-05
DOI:
EISSN:
1533-4406
ISSN:
0028-4793
URN:
uuid:9a058ccf-4bcd-4992-9d62-789a587f975a
Source identifiers:
445962
Local pid:
pubs:445962

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