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HIV-1 promotes the degradation of components of the Type 1 IFN JAK/STAT 1 pathway and blocks antiviral ISG induction

Abstract:

Anti-retroviral therapy successfully suppresses HIV-1 infection, but fails to provide a cure. During infection Type 1 IFNs normally play an essential role in viral clearance, but in vivo IFN-a only has a modest impact on HIV-1 infection, suggesting its possible targeting by HIV. Here, we report that the HIV protein, Vif, inhibits effective IFN-a signalling via degradation of essential JAK/STAT pathway components. We found that STAT1 and STAT3 are specifically reduced in HEK293T cells expressi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.ebiom.2018.03.006

Authors


Napoletano, S More by this author
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Funding agency for:
Stevenson, NJ
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Funding agency for:
Stevenson, NJ
Publisher:
Elsevier Publisher's website
Journal:
EBioMedicine Journal website
Volume:
30
Pages:
203-216
Publication date:
2018-03-08
Acceptance date:
2018-03-07
DOI:
ISSN:
2352-3964
Pubs id:
pubs:828263
URN:
uri:9a04a209-189a-43f7-9a48-67f287bf451c
UUID:
uuid:9a04a209-189a-43f7-9a48-67f287bf451c
Local pid:
pubs:828263

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