- Abstract:
- Sulfones feature prominently in biologically active molecules and are key functional groups for organic synthesis. We report a mild, photoredox-catalyzed reaction for sulfonylation of aniline derivatives with sulfinate salts, and demonstrate the utility of the method by the late-stage functionalization of drugs. Key features of the method are the straightforward generation of sulfonyl radicals from bench-stable sulfinate salts and the use of simple aniline derivatives as convenient readily available coupling partners.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 1.2MB)
-
- Publisher copy:
- 10.1039/C7SC03891G
-
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- Publisher:
- Royal Society of Chemistry Publisher's website
- Journal:
- Chemical Science Journal website
- Volume:
- 9
- Issue:
- 3
- Pages:
- 629-633
- Publication date:
- 2017-11-16
- Acceptance date:
- 2017-11-07
- DOI:
- EISSN:
-
2041-6539
- ISSN:
-
2041-6520
- Pubs id:
-
pubs:745712
- URN:
-
uri:99f695d3-097e-42ef-832e-043c41d03765
- UUID:
-
uuid:99f695d3-097e-42ef-832e-043c41d03765
- Local pid:
- pubs:745712
- Paper number:
- 3
- Copyright date:
- 2017
- Notes:
- This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Journal article
Direct sulfonylation of anilines mediated by visible light
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UCB Pharma
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John Fell Fund
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