OBJECTIVE: Our objective was to characterize the pharmacokinetic properties of sulfadoxine-pyrimethamine in African adults and children with acute falciparum malaria. Despite decades of widespread use, there are few data to inform dose recommendations. METHODS: In a prospective multicenter pharmacokinetic study in 307 patients with acute falciparum malaria, capillary blood concentrations of sulfadoxine and pyrimethamine were determined at 9 visits over a period of 42 days by mass spectrometr...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
Sulfadoxine-pyrimethamine pharmacokinetics in malaria: pediatric dosing implications.
If you are the owner of this record, you can report an update to it here: Report update to this record