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Sulfadoxine-pyrimethamine pharmacokinetics in malaria: pediatric dosing implications.

Abstract:

OBJECTIVE: Our objective was to characterize the pharmacokinetic properties of sulfadoxine-pyrimethamine in African adults and children with acute falciparum malaria. Despite decades of widespread use, there are few data to inform dose recommendations. METHODS: In a prospective multicenter pharmacokinetic study in 307 patients with acute falciparum malaria, capillary blood concentrations of sulfadoxine and pyrimethamine were determined at 9 visits over a period of 42 days by mass spectrometr...

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Publication status:
Published

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Publisher copy:
10.1016/j.clpt.2006.08.016

Authors


Barnes, KI More by this author
Watkins, WM More by this author
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Journal:
Clinical pharmacology and therapeutics
Volume:
80
Issue:
6
Pages:
582-596
Publication date:
2006-12-05
DOI:
EISSN:
1532-6535
ISSN:
0009-9236
URN:
uuid:99ee68b5-12e5-4aaf-939c-9d4bef483a5e
Source identifiers:
40175
Local pid:
pubs:40175

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