Journal article

Butane-2,3-diacetal-desymmetrized glycolic acid—a new building block for the stereoselective synthesis of enantiopure α-hydroxy acids

Abstract:: According to a chiral memory protocol, a chiral glycolic acid equivalent, the butane-2,3-diacetal-desymmetrized glycolate 2, is obtained from chiral 3-halopropane-1,2-diols 1. Compound 2 is a new and effective building block for the synthesis of mono- and dialkylated α-hydroxy acids 3, which constitute a biologically and pharmacologically important structural motif.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Díez, E., Dixon, D., & Ley, S. (2001). Butane-2,3-diacetal-desymmetrized glycolic acid—a new building block for the stereoselective synthesis of enantiopure α-hydroxy acids. Angewandte Chemie (International Ed. in English), 40(15), 2906–2909.

MLA Style

Díez, E, et al. “Butane-2,3-Diacetal-Desymmetrized Glycolic Acid—a New Building Block for the Stereoselective Synthesis of Enantiopure α-Hydroxy Acids.” Angewandte Chemie (International Ed. in English), vol. 40, no. 15, 2001, pp. 2906–09.

Chicago Style

Díez, E, D Dixon, and S Ley. 2001. “Butane-2,3-Diacetal-Desymmetrized Glycolic Acid—a New Building Block for the Stereoselective Synthesis of Enantiopure α-Hydroxy Acids.” Angewandte Chemie (International Ed. in English) 40 (15): 2906–9.
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Publisher copy:: 10.1002/1521-3773(20010803)40:15<2906::aid-anie2906>3.0.co;2-5

Authors

+ Díez, E More by this author

Role:: Author

+ Dixon, D More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

+ Ley, S More by this author

Role:: Author

Publisher:: Wiley-VCH
Journal:: Angewandte Chemie (International ed. in English) More from this journal
Volume:: 40
Issue:: 15
Pages:: 2906-2909
Publication date:: 2001-08-01
DOI:: 10.1002/1521-3773(20010803)40:15<2906::aid-anie2906>3.0.co;2-5
EISSN:: 1521-3773
ISSN:: 1433-7851

Language:: English
Keywords:: chiral memory

alkylation

asymmetric synthesis

alpha-hydroxy acids

diastereoselectivity
UUID:: uuid:9999de0d-2090-447e-a814-71ff6dfb49ef
Local pid:: pubs:52090
Source identifiers:: 52090
Deposit date:: 2012-12-19
ARK identifier:: ark:/29072/ora_9999de0d2090447ea81471ff6dfb49ef

Terms of use

Copyright holder:: WILEY-VCH Verlag GmbH, Weinheim, Fed Rep of Germany
Copyright date:: 2001
Notes:: Copyright © 2001 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany.

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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