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Activation of a G protein-coupled receptor through indirect antibody-mediated tethering of ligands

Abstract:
The use of antibodies to target membrane receptors enables specific and potent activation. But antibodies with appropriate specificity can be lacking. We present methods for targeting receptors without target-specific antibodies.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1039/d1cb00118c

Authors

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Role:
Author
ORCID:
0000-0001-9871-8333
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Institution:
University of Oxford
Role:
Author
ORCID:
0000-0002-4116-9879
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Role:
Author
ORCID:
0000-0002-2163-5772
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Role:
Author
ORCID:
0000-0002-1090-6071


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Funder identifier:
10.13039/100000002
Grant:
1DP1AI150593
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Funder identifier:
10.13039/100000884


Publisher:
Royal Society of Chemistry
Journal:
RSC Chemical Biology More from this journal
Volume:
2
Issue:
6
Pages:
1692-1700
Publication date:
2021-12-02
DOI:
EISSN:
2633-0679
ISSN:
2633-0679


Language:
English
Keywords:
Pubs id:
1217993
Local pid:
pubs:1217993
Source identifiers:
W3205837077
Deposit date:
2026-04-08
ARK identifier:
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