Nanoparticle delivery systems formed using electrically sprayed co-flowing excipients and active agent.
The high production rate generation of drug-loaded biodegradable nanoparticles is a crucial factor in achieving significant and rapid advances in nanomedicine. In this paper, we report a one-step, high yield, coaxial electrohydrodynamic spraying method for generating insulin-loaded polymeric nanoparticles. Poly(lactic-co-glycolic acid) copolymer (PLGA) was used as the model biodegradable polymer. The particle shape and size-distribution were studied using electron and atomic force microscopy ...Expand abstract
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