Long-term stability of antibody responses elicited by Dengue virus envelope DIII-based DNA vaccines

Journal article

Dengue virus (DENV) is one the most important viral pathogens worldwide. Currently there is an imperative need for a reliable vaccine capable of inducing durable protection against all four serotypes. We have previously reported strongly neutralizing and highly specific antibody responses from all four serotypes to a DNA vaccine based on an engineered version of DENV E protein's domain III (DIII). Here, we show that monovalent and tetravalent immunizations with the DIII-based DNA vaccines are also capable of inducing highly stable antibody responses that remain strongly neutralizing over long periods of time. Our results demonstrate that DNA-vaccinated mice maintain a strong antibody response in terms of titre, avidity and virus-neutralizing capability 1 year after immunization.

Authors: Slon Campos, J; Poggianella, M; Burrone, O

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Microbiology Society
• Journal: Journal of General Virology
• Publication date: 2018-06-20
• Acceptance date: 2018-05-24
• DOI: 10.1099/jgv.0.001094
• EISSN: 1465-2099
• ISSN: 0022-1317
• Pmid: 29923817
• Language: English
• Keywords: Dengue virus; envelope protein; Dengue; flaviviruses; DNA vaccine; genetic vaccines