Understanding COVID-19 via comparative analysis of dark proteomes of SARS-CoV-2, human SARS and bat SARS-like coronaviruses

Journal article

This review examines the significance of intrinsically disordered proteins (IDPs) and regions to viruses and their prospects as vaccine components. Using a content analysis of scientific articles, reviews, interviews, industry updates and magazines, it demonstrates how intrinsically disordered proteins support virus infections allowing them to subvert the host immune response, facilitate virus evolution, conserve genomic space, and enhance viral stability. It also shows that protein biologics are being challenged in the pharmaceutical industry with the rise of mRNA technology in therapeutics and vaccines. While some findings additionally indicate strong potential for targeting IDPs particularly in the treatment of cancer and neurological disorders, this study proposes the possible function of IDPs as excipients for the stabilization of other biologics.Cellular and Molecular Biolog

Authors: Giri, R; Bhardwaj, T; Shegane, M; Gehi, BR; Kumar, P

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Springer
• Journal: Cellular and Molecular Life Sciences
• Volume: 78
• Issue: 4
• Pages: 1655-1688
• Publication date: 2020-07-25
• DOI: 10.1007/s00018-020-03603-x
• EISSN: 1420-9071
• ISSN: 1420-682X
• Language: English
• Keywords: Severe acute respiratory syndrome coronavirus; Genetics; Sars virus; Virus; Virology; Coronavirus; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Proteome; Infectious disease (medical specialty); Pandemic; Medicine; Betacoronavirus; Infectivity; Disease; Biology; Coronavirus disease 2019 (COVID-19)