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The effect of mutations in the lid region of Thermomyces lanuginosus lipase on interactions with triglyceride surfaces: a multi-scale simulation study

Abstract:

Lipases naturally function at the interface formed between amphiphilic molecules and the aqueous environment. Thermomyces lanuginosus lipase (TLL) is a well-characterised lipase, known to exhibit interfacial activation during which a lid region covering the active site becomes displaced upon interaction with an interface. In this study, we investigate the effect the amino acid sequence of the lid region on interfacial binding and lid dynamics of TLL. Three TLL variants were investigated, a wi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.chemphyslip.2017.08.004

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Department:
Oxford, MSD, Biochemistry
Lelimousin, M More by this author
Skjold-Jorgensen, J More by this author
Svendsen, A More by this author
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Department:
Christ Church
Publisher:
Elsevier Publisher's website
Journal:
Chemistry and Physics of Lipids Journal website
Volume:
211
Pages:
4-15
Publication date:
2017-08-15
Acceptance date:
2017-08-08
DOI:
EISSN:
1873-2941
ISSN:
0009-3084
Pubs id:
pubs:712482
URN:
uri:9907ccef-30a1-49b7-ac97-de86a094a7e1
UUID:
uuid:9907ccef-30a1-49b7-ac97-de86a094a7e1
Local pid:
pubs:712482

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