Journal article
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.
- Abstract:
-
Ankylosing spondylitis is a common form of inflammatory arthritis predominantly affecting the spine and pelvis that occurs in approximately 5 out of 1,000 adults of European descent. Here we report the identification of three variants in the RUNX3, LTBR-TNFRSF1A and IL12B regions convincingly associated with ankylosing spondylitis (P < 5 × 10(-8) in the combined discovery and replication datasets) and a further four loci at PTGER4, TBKBP1, ANTXR2 and CARD9 that show strong association acro...
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- Publication status:
- Published
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- Publisher copy:
- 10.1038/ng.873
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Authors
Bibliographic Details
- Journal:
- Nature genetics
- Volume:
- 43
- Issue:
- 8
- Pages:
- 761-767
- Publication date:
- 2011-08-01
- DOI:
- EISSN:
-
1546-1718
- ISSN:
-
1061-4036
- Source identifiers:
-
171875
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:171875
- UUID:
-
uuid:98c354cc-d9bb-45fc-80af-231a6fe59039
- Local pid:
- pubs:171875
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2011
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