Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.

Evans, DM; Spencer, CC; Pointon, JJ; Su, Z; Harvey, D; Kochan, G; Oppermann, U; Dilthey, A; Pirinen, M; Stone, MA; Appleton, L; Moutsianas, L; Leslie, S; Wordsworth, T; Kenna, TJ; Karaderi, T; Thomas, GP; Ward, MM; Weisman, MH; Farrar, C; Bradbury, LA; Danoy, P; Inman, RD; Maksymowych, W; Gladman, D; Rahman, P; Morgan, A; Marzo-Ortega, H; Bowness, P; Gaffney, K; Gaston, JS; Smith, M; Bruges-Armas, J; Couto, AR; Sorrentino, R; Paladini, F; Ferreira, MA; Xu, H; Liu, Y; Jiang, L; Lopez-Larrea, C; Díaz-Peña, R; López-Vázquez, A; Zayats, T; Band, G; Bellenguez, C; Blackburn, H; Blackwell, JM; Bramon, E; Bumpstead, SJ; Casas, JP; Corvin, A; Craddock, N; Deloukas, P; Dronov, S; Duncanson, A; Edkins, S; Freeman, C; Gillman, M; Gray, E; Gwilliam, R; Hammond, N; Hunt, SE; Jankowski, J; Jayakumar, A; Langford, C; Liddle, J; Markus, HS; Mathew, CG; McCann, OT; McCarthy, MI; Palmer, CN; Peltonen, L; Plomin, R; Potter, SC; Rautanen, A; Ravindrarajah, R; Ricketts, M; Samani, N; Sawcer, SJ; Strange, A; Trembath, RC; Viswanathan, AC; Waller, M; Weston, P; Whittaker, P; Widaa, S; Wood, NW; McVean, G; Reveille, JD; Wordsworth, BP; Brown, MA; Donnelly, P

Abstract:

Ankylosing spondylitis is a common form of inflammatory arthritis predominantly affecting the spine and pelvis that occurs in approximately 5 out of 1,000 adults of European descent. Here we report the identification of three variants in the RUNX3, LTBR-TNFRSF1A and IL12B regions convincingly associated with ankylosing spondylitis (P < 5 × 10(-8) in the combined discovery and replication datasets) and a further four loci at PTGER4, TBKBP1, ANTXR2 and CARD9 that show strong association acro...

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APA Style

Evans, D. M., Spencer, C. C., Pointon, J. J., Su, Z., Harvey, D., Kochan, G., Oppermann, U., Dilthey, A., Pirinen, M., Stone, M. A., Appleton, L., Moutsianas, L., Leslie, S., Wordsworth, T., Kenna, T. J., Karaderi, T., Thomas, G. P., Ward, M. M., Weisman, M. H., … Donnelly, P. (2011). Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nature Genetics, 43(8), 761–767.

MLA Style

Evans, D. M., et al. “Interaction between ERAP1 and HLA-B27 in Ankylosing Spondylitis Implicates Peptide Handling in the Mechanism for HLA-B27 in Disease Susceptibility.” Nature Genetics, vol. 43, no. 8, 2011, pp. 761–67.

Chicago Style

Evans, DM, CC Spencer, JJ Pointon, Z Su, D Harvey, G Kochan, U Oppermann, et al. 2011. “Interaction between ERAP1 and HLA-B27 in Ankylosing Spondylitis Implicates Peptide Handling in the Mechanism for HLA-B27 in Disease Susceptibility.” Nature Genetics 43 (8): 761–67.
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