Journal article : Review
African Plasmodium vivax malaria improbably rare or benign
- Abstract:
- The overwhelming dominance of Duffy blood group negativity among most people living in sub-Saharan Africa has been considered the basis of their protection from endemic Plasmodium vivax malaria. New evidence demonstrates widespread transmission of P. vivax in Duffy-negative Africa, though currently of unknown distribution, magnitude, or consequences. Other new evidence from outside of Africa demonstrates marked tropisms of P. vivax for extravascular tissues of bone marrow and spleen. Those establish states of proliferative infection with low-grade or undetectable parasitemia of peripheral blood causing acute and chronic disease. This review examines the plausibility of those infectious processes also operating in Duffy-negative Africans and causing harm of unrecognized origin.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.8MB, Terms of use)
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- Publisher copy:
- 10.1016/j.pt.2022.05.006
Authors
- Publisher:
- Cell Press
- Journal:
- Trends in Parasitology More from this journal
- Volume:
- 38
- Issue:
- 8
- Pages:
- 683-696
- Place of publication:
- England
- Publication date:
- 2022-06-03
- Acceptance date:
- 2022-05-10
- DOI:
- EISSN:
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1471-5007
- ISSN:
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1471-4922
- Pmid:
-
35667992
- Language:
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English
- Keywords:
- Subtype:
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Review
- Pubs id:
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1263883
- Local pid:
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pubs:1263883
- Deposit date:
-
2025-01-14
- ARK identifier:
Terms of use
- Copyright holder:
- J. Kevin Baird
- Copyright date:
- 2022
- Rights statement:
- © 2022 The Author. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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