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Timing of the onset of changes in renal energetics in relation to blood pressure and glomerular filtration in haemorrhagic hypotension in the rat.

Abstract:

The timing and circumstances of changes in renal energetics during the gradual induction of haemorrhagic hypotension were studied in anaesthetised rats by phosphorus-31 nuclear magnetic resonance. Animals were bled at a constant rate of 0.1 ml/min via the femoral artery. Whenever changes in renal energetics were seen, a similar pattern was observed. A decrease in adenosine triphosphate occurred rapidly and was always associated with accumulation of inorganic phosphate and tissue acidosis. Pro...

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Publication status:
Published

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Publisher copy:
10.1159/000185290

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, Biomedical Research Centre
Role:
Author
Journal:
Nephron
Volume:
51
Issue:
2
Pages:
225-232
Publication date:
1989-01-01
DOI:
EISSN:
1423-0186
ISSN:
0028-2766
URN:
uuid:9894a523-fa02-43c9-bf91-ecccf61e68b9
Source identifiers:
16897
Local pid:
pubs:16897

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