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The role of the priming loop in influenza A virus RNA synthesis

Abstract:

RNA-dependent RNA polymerases (RdRps) are used by RNA viruses to replicate and transcribe their RNA genomes1 . They adopt a closed, right-handed fold with conserved subdomains called palm, fingers and thumb1,2. Conserved RdRp motifs A–F coordinate the viral RNA template, NTPs and magnesium ions to facilitate nucleotide condensation1 . For the initiation of RNA synthesis, most RdRps use either a primer-dependent or de novo mechanism3. The influenza A virus RdRp, in contrast, uses a capped RNA ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/nmicrobiol.2016.29

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Institution:
University of Oxford
Department:
Oxford, MPLS, Physics
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Institution:
University of Oxford
Department:
Oxford, MPLS, Physics
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Funding agency for:
Te Velthuis, AJW
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Funding agency for:
Te Velthuis, AJW
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Funding agency for:
Kapanidis, A
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Publisher:
Nature Publisher's website
Journal:
Nature Microbiology Journal website
Publication date:
2016-03-21
DOI:
ISSN:
2058-5276
URN:
uuid:989253eb-b80c-4a63-92bb-72dcad67bc8f
Source identifiers:
609911
Local pid:
pubs:609911

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