Journal article
Cardiac glycosides induce cell death in human cells by inhibiting general protein synthesis
- Abstract:
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BACKGROUND: Cardiac glycosides are Na(+)/K(+)-pump inhibitors widely used to treat heart failure. They are also highly cytotoxic, and studies have suggested specific anti-tumor activity leading to current clinical trials in cancer patients. However, a definitive demonstration of this putative anti-cancer activity and the underlying molecular mechanism has remained elusive. METHODOLOGY/PRINCIPAL FINDINGS: Using an unbiased transcriptomics approach, we found that cardiac glycosides inhibit gen...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 697.1KB, Terms of use)
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- Publisher copy:
- 10.1371/journal.pone.0008292
Authors
Bibliographic Details
- Publisher:
- Public Library of Science
- Journal:
- PLoS ONE More from this journal
- Volume:
- 4
- Issue:
- 12
- Pages:
- e8292
- Publication date:
- 2009-12-16
- Acceptance date:
- 2009-11-19
- DOI:
- EISSN:
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1932-6203
Item Description
- Language:
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English
- Keywords:
- UUID:
-
uuid:988fc38f-2277-479b-a309-b6c7ece1a03f
- Local pid:
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pubs:489983
- Source identifiers:
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489983
- Deposit date:
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2014-11-20
Terms of use
- Copyright holder:
- Perne et al
- Copyright date:
- 2009
- Notes:
- © 2009 Perne et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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