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Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen.

Abstract:

The response of animals to hypoxia is mediated by the hypoxia-inducible transcription factor. Human hypoxia-inducible factor is regulated by four Fe(II)- and 2-oxoglutarate-dependent oxygenases: prolyl hydroxylase domain enzymes 1-3 catalyse hydroxylation of two prolyl-residues in hypoxia-inducible factor, triggering its degradation by the proteasome. Factor inhibiting hypoxia-inducible factor catalyses the hydroxylation of an asparagine-residue in hypoxia-inducible factor, inhibiting its tra...

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Publication status:
Published

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Authors


Flashman, E More by this author
Hoffart, LM More by this author
Bollinger Jr, JM More by this author
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Journal:
FEBS J
Volume:
277
Issue:
19
Pages:
4089-4099
Publication date:
2010-08-31
DOI:
EISSN:
1742-4658
ISSN:
1742-464X
URN:
uuid:988e407c-541a-4f4e-ad4b-bddc787d276b
Source identifiers:
71153
Local pid:
pubs:71153

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