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Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance.

Abstract:

Local hypoxia in hematopoietic stem cell (HSC) niches is thought to regulate HSC functions. Hypoxia-inducible factor-1 (Hif-1) and Hif-2 are key mediators of cellular responses to hypoxia. Although oxygen-regulated α-subunits of Hifs, namely Hif-1α and Hif-2α, are closely related, they play overlapping and also distinct functions in nonhematopoietic tissues. Although Hif-1α-deficient HSCs lose their activity on serial transplantation, the role for Hif-2α in cell-autonomous HSC maintenance rem...

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Publication status:
Published

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Authors


Guitart, AV More by this author
Subramani, C More by this author
Armesilla-Diaz, A More by this author
Sepulveda, C More by this author
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Journal:
Blood
Volume:
122
Issue:
10
Pages:
1741-1745
Publication date:
2013-09-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:985ea4bf-8b2d-4577-8d50-abf01319f31f
Source identifiers:
415803
Local pid:
pubs:415803

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