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Journal article

Hydrophobic gating in ion channels.

Abstract:

Biological ion channels are nanoscale transmembrane pores. When water and ions are enclosed within the narrow confines of a sub-nanometer hydrophobic pore, they exhibit behavior not evident from macroscopic descriptions. At this nanoscopic level, the unfavorable interaction between the lining of a hydrophobic pore and water may lead to stochastic liquid-vapor transitions. These transient vapor states are "dewetted", i.e. effectively devoid of water molecules within all or part of the pore, th...

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Publication status:
Published

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Publisher copy:
10.1016/j.jmb.2014.07.030

Authors


Sansom, MS More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Physics, Condensed Matter Physics
Journal:
Journal of molecular biology
Volume:
427
Issue:
1
Pages:
121-130
Publication date:
2015-01-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:980c1aa9-012f-4949-8b61-014b30074061
Source identifiers:
481013
Local pid:
pubs:481013

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