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Double T cell depletion of bone marrow using sequential positive and negative cell immunoaffinity or CD34+ cell selection followed by Campath-1M; effect on CD34+ cells and progenitor cell recoveries.

Abstract:

An advantage of CD34+ cell selection over antibody purging is that a component allograft is produced comprising a stem cell enriched and an unadsorbed fraction, the latter containing T cells which may be used for post-transplant immunotherapy. Initial reports with PBSC allografts suggested that T cell depletion (TCD) by CD34+ cell selection and post-graft cyclosporin A +/- methotrexate was insufficient prophylaxis against acute GVHD. We compared sequential TCD (of a CD34+ cell-selected fracti...

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Publication status:
Published

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Publisher copy:
10.1038/sj.bmt.1701296

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Journal:
Bone marrow transplantation
Volume:
22
Issue:
2
Pages:
117-124
Publication date:
1998-07-05
DOI:
EISSN:
1476-5365
ISSN:
0268-3369
URN:
uuid:97fdb861-80ab-4a44-b528-01226819cded
Source identifiers:
4914
Local pid:
pubs:4914

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