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Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk.

Abstract:

Osteoporotic fracture is a major cause of morbidity and mortality worldwide. Low bone mineral density (BMD) is a major predisposing factor to fracture and is known to be highly heritable. Site-, gender-, and age-specific genetic effects on BMD are thought to be significant, but have largely not been considered in the design of genome-wide association studies (GWAS) of BMD to date. We report here a GWAS using a novel study design focusing on women of a specific age (postmenopausal women, age 5...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pgen.1001372

Authors


Duncan, EL More by this author
McCloskey, E More by this author
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Australian Cancer Research Foundation More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS genetics Journal website
Volume:
7
Issue:
4
Pages:
Article: e1001372
Publication date:
2011-04-05
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
URN:
uuid:97f6393d-9432-4d57-a7d7-e96b5eb33200
Source identifiers:
138802
Local pid:
pubs:138802

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