Use of methylmalonyl‐CoA epimerase in enhancing crotonase stereoselectivity

Hamed, R; Gomez-Castellanos, J; Sean Froese, D; Krysztofinska, E; Yue, W; Schofield, C

Journal article

Use of methylmalonyl‐CoA epimerase in enhancing crotonase stereoselectivity

Abstract:: The use of methylmalonyl‐CoA epimerase (MCEE) to improve stereoselectivity in crotonase‐mediated biocatalysis is exemplified by the coupling of MCEE, crotonyl‐CoA carboxylase reductase and carboxymethylproline synthase in a three‐enzyme one‐pot sequential synthesis of functionalised C‐5 carboxyalkylprolines starting from crotonyl‐CoA and carbon dioxide.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Hamed, R., Gomez-Castellanos, J., Sean Froese, D., Krysztofinska, E., Yue, W., & Schofield, C. (2015). Use of methylmalonyl‐CoA epimerase in enhancing crotonase stereoselectivity. Chembiochem : a European Journal of Chemical Biology, 17(6), 471–473.

MLA Style

Hamed, R., et al. “Use of Methylmalonyl‐CoA Epimerase in Enhancing Crotonase Stereoselectivity.” Chembiochem : a European Journal of Chemical Biology, vol. 17, no. 6, Wiley, 2015, pp. 471–73.

Chicago Style

Hamed, R, J Gomez-Castellanos, D Sean Froese, E Krysztofinska, W Yue, and C Schofield. 2015. “Use of Methylmalonyl‐CoA Epimerase in Enhancing Crotonase Stereoselectivity.” Chembiochem : a European Journal of Chemical Biology 17 (6): 471–73.
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Publisher copy:: 10.1002/cbic.201500644

Authors

+ Hamed, R More by this author

Role:: Author

+ Gomez-Castellanos, J More by this author

Role:: Author

+ Sean Froese, D More by this author

Role:: Author

+ Krysztofinska, E More by this author

Role:: Author

+ Yue, W More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDM
Sub department:: Structural Genomics Consortium
Role:: Author

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+ 106169/Wellcome Trust More from this funder

+ Canadian Institutes of Health Research More from this funder

+ Biotechnology and Biological Sciences Research Council More from this funder

+ 092809/Z/10/Z/Wellcome Trust More from this funder

Publisher:: Wiley
Journal:: Chembiochem : a European journal of chemical biology More from this journal
Volume:: 17
Issue:: 6
Pages:: 471-473
Publication date:: 2015-12-30
DOI:: 10.1002/cbic.201500644
EISSN:: 1439-7633
ISSN:: 1439-4227
Pmid:: 26716911

Language:: English
Keywords:: carbapenem

enolate reactivity

antibiotics

SBTMR

stereoselectivity

dynamic kinetic discrimination

biosynthesis

crotonases
Pubs id:: pubs:586529
UUID:: uuid:97ee6487-a833-4e0c-bcaf-f507c8ce1b5b
Local pid:: pubs:586529
Source identifiers:: 586529
Deposit date:: 2017-03-07

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Copyright holder:: Wiley

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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Journal article

Use of methylmalonyl‐CoA epimerase in enhancing crotonase stereoselectivity

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Use of methylmalonyl‐CoA epimerase in enhancing crotonase stereoselectivity

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