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Induction of immunological tolerance as a therapeutic procedure

Abstract:

A major goal of immunosuppressive therapies is to harness immune tolerance mechanisms so as to minimize unwanted side effects associated with protracted immunosuppressive therapy. Antibody blockade of lymphocyte coreceptor and costimulatory pathways in mice has demonstrated the principle that both naive and primed immune systems can be reprogrammed toward immunological tolerance. Such tolerance can involve the amplification of activity of regulatory T cells, and is maintained through continuo...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0001-7519-6720
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0003-1206-4880
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Name:
European Commission
Grant:
339402
Publisher:
American Society for Microbiology
Journal:
Microbiology Spectrum More from this journal
Volume:
4
Issue:
4
Article number:
22
Publication date:
2016-07-15
Acceptance date:
2015-09-23
DOI:
EISSN:
2165-0497
ISSN:
2165-0497
Pmid:
27726804
Language:
English
Pubs id:
pubs:832266
UUID:
uuid:97c908f4-fff1-4272-b515-8be6f7e49ab6
Local pid:
pubs:832266
Source identifiers:
832266
Deposit date:
2018-06-04

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