Journal article icon

Journal article

Glutamine analogs promote cytoophidium assembly in human and Drosophila cells.

Abstract:

CTP synthase is compartmentalized within a subcellular structure, termed the cytoophidium, in a range of organisms including bacteria, yeast, fruit fly and rat. Here we show that CTP synthase is also compartmentalized into cytoophidia in human cells. Surprisingly, the occurrence of cytoophidia in human cells increases upon treatment with a glutamine analog 6-diazo-5-oxo-l-norleucine (DON), an inhibitor of glutamine-dependent enzymes including CTP synthase. Experiments in flies confirmed that ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

Actions


Access Document


Publisher copy:
10.1016/j.jgg.2011.08.004

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Expand authors...
Medical Research Council More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Journal of Genetics and Genomics Journal website
Volume:
38
Issue:
9
Pages:
391-402
Publication date:
2011-08-17
DOI:
EISSN:
1873-5533
ISSN:
1673-8527
URN:
uuid:97c5c576-fff7-4fdc-8eb7-373e47bd953a
Source identifiers:
179970
Local pid:
pubs:179970

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP