Psychedelics as moral bioenhancers: protocol for a scoping review of ethical arguments for and against

Journal article

Background
Moral bioenhancement typically refers to the deliberate use of drugs or biotechnologies, potentially alongside other practices, to attempt to improve oneself morally. In addition to general concerns regarding moral self-bioenhancement, the possibility of using psychedelic substances for such purposes raises distinct ethical questions. As a first step in analysing these questions, we intend to perform a scoping review of the existing arguments for and against the use of psychedelics as moral bioenhancers. We will focus primarily on voluntary use by individuals, although voluntary use by couples or small groups will be considered. The present contribution is a protocol for this scoping review.
Methods
Our scoping review will adhere to the Joanna Briggs Institute methodology, which involves five stages: (1) identifying the research question, (2) developing the search strategy, (3) setting inclusion criteria, (4) extracting data, and (5) presenting and analysing the results. We will include both published and unpublished sources if they explicitly present ethical arguments for or against the voluntary use of psychedelics as intentional moral bioenhancers in adults. We will search for relevant studies in Embase, MEDLINE, Web of Science, Google Scholar, The National Library of Medicine, the Cumulated Index to Nursing and Allied Health Literature, Philosopher’s Index, the Bioethics Literature Database, EthxWeb, PhilPapers, Stanford Encyclopedia of Philosophy, Philosopher’s Index, EBSCO, BASE, and WorldCat. Sources will be excluded if (a) the full text is inaccessible, (b) the main text is in a language other than English, or (c) the focus is not primarily on ethical arguments (for example, focusing primarily on the clinical use of psychedelics for treatment). Two raters will independently assess all articles for eligibility, with disagreements to be resolved with a third reviewer. Data from eligible articles will be charted using a standardised data extraction form. The data will be analysed following PRISMA-ScR guidelines.

Authors: Streicher, S; Register, C; Lim, X; Barış, M; Porsdam Mann, S

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: F1000Research
• Journal: Wellcome Open Research
• Volume: 10
• Article number: 3
• Place of publication: England
• Publication date: 2025-01-13
• Acceptance date: 2025-03-24
• DOI: 10.12688/wellcomeopenres.23414.1
• EISSN: 2398-502X
• Pmid: 40134829
• Language: English
• Keywords: psychedelic; bioenhancement; scoping review; protocol; moral enhancement; hallucinogen