Journal article
A healthy dietary pattern associates with a lower risk of a first clinical diagnosis of central nervous system demyelination
- Abstract:
-
Background:
The evidence associating diet and risk of multiple sclerosis is inconclusive.
Objective:
We investigated associations between dietary patterns and risk of a first clinical diagnosis of central nervous system demyelination, a common precursor to multiple sclerosis.
Methods:
We used data from the 2003–2006 Ausimmune Study, a case–control study examining environmental risk factors for a first clinical diagnosis of central nervous system demyelination, with participants matched on age, sex and study region. Using data from a food frequency questionnaire, dietary patterns were identified using principal component analysis. Conditional logistic regression models (n = 698, 252 cases, 446 controls) were adjusted for history of infectious mononucleosis, serum 25-hydroxyvitamin D concentrations, smoking, race, education, body mass index and dietary misreporting.
Results:
We identified two major dietary patterns – healthy (high in poultry, fish, eggs, vegetables, legumes) and Western (high in meat, full-fat dairy; low in wholegrains, nuts, fresh fruit, low-fat dairy), explaining 9.3% and 7.5% of variability in diet, respectively. A one-standard deviation increase in the healthy pattern score was associated with a 25% reduced risk of a first clinical diagnosis of central nervous system demyelination (adjusted odds ratio 0.75; 95% confidence interval 0.60, 0.94; p = 0.011). There was no statistically significant association between the Western dietary pattern and risk of a first clinical diagnosis of central nervous system demyelination.
Conclusion:
Following healthy eating guidelines may be beneficial for those at high risk of multiple sclerosis.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Accepted manuscript, 774.5KB, Terms of use)
-
- Publisher copy:
- 10.1177/1352458518793524
- Publisher:
- SAGE Publications
- Journal:
- Multiple Sclerosis Journal More from this journal
- Volume:
- 25
- Issue:
- 11
- Pages:
- 1514-1525
- Publication date:
- 2018-08-07
- Acceptance date:
- 2018-07-18
- DOI:
- EISSN:
-
1477-0970
- ISSN:
-
1352-4585
- Pmid:
-
30084751
- Language:
-
English
- Keywords:
- Pubs id:
-
1063886
- Local pid:
-
pubs:1063886
- Deposit date:
-
2020-05-27
Terms of use
- Copyright holder:
- Black, LJ et al.
- Copyright date:
- 2019
- Rights statement:
- © The Author(s), 2018.
If you are the owner of this record, you can report an update to it here: Report update to this record