- Abstract:
- The alignment of the 2-picoline ligand within the major groove contributes to the formation of a highly stereoselective GG intrastrand bischelate between the new anticancer drug cis-[PtCl2(NH3)(2-picoline)] and a 14-mer DNA duplex (see schematic representation).
- Publication status:
- Published
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- Journal:
- ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Volume:
- 38
- Issue:
- 13-14
- Pages:
- 2060-2063
- Publication date:
- 1999-01-01
- DOI:
- EISSN:
-
1521-3773
- ISSN:
-
1433-7851
- URN:
-
uuid:979edff7-bad9-4e43-bfd5-b352e7199645
- Source identifiers:
-
400255
- Local pid:
- pubs:400255
- Language:
- English
- Keywords:
- Copyright date:
- 1999
Journal article
A new platinum anticancer drug forms a highly stereoselective adduct with duplex DNA
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