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A new platinum anticancer drug forms a highly stereoselective adduct with duplex DNA

Abstract:
The alignment of the 2-picoline ligand within the major groove contributes to the formation of a highly stereoselective GG intrastrand bischelate between the new anticancer drug cis-[PtCl2(NH3)(2-picoline)] and a 14-mer DNA duplex (see schematic representation).
Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume:
38
Issue:
13-14
Pages:
2060-2063
Publication date:
1999-01-01
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
URN:
uuid:979edff7-bad9-4e43-bfd5-b352e7199645
Source identifiers:
400255
Local pid:
pubs:400255

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