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Discriminated selection among viral peptides with the appropriate anchor residues: implications for the size of the cytotoxic T-lymphocyte repertoire and control of viral infection.

Abstract:

Structural characterization of peptides restricted by major histocompatibility complex (MHC) class I molecules has identified residues critical for MHC class I binding and for T-cell receptor recognition. For example, optimal peptides fitting into the murine MHC class I Db groove are 9 to 11 amino acids long and require as MHC anchor residues an Asn (N) at position 5 and also either a hydrophobic residue, a Met (M) or a Cys (C), at the carboxy terminus. The three known Db-restricted peptides ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Role:
Author
Journal:
Journal of virology
Volume:
69
Issue:
12
Pages:
7423-7429
Publication date:
1995-12-05
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:979e3433-857a-483e-ad1d-61686dab6a06
Source identifiers:
35607
Local pid:
pubs:35607

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