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Concentrations of IGF-I and IGFBP-3 and brain tumor risk in the European Prospective Investigation into Cancer and Nutrition.

Abstract:

BACKGROUND: Insulin-like growth factor-1 (IGF-I) is important in normal brain development but in the adult brain, IGF-I overexpression may be a risk factor for tumor development. METHODS: We examined the association between circulating concentrations of IGF-I and IGFBP-3 in relation to risk of gliomas (74 low-grade, 206 high-grade gliomas), meningiomas (n = 174) and acoustic neuromas (n = 49) by using a case-control design nested in the European Prospective Investigation into Cancer and Nutri...

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Publication status:
Published

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Authors


Rohrmann, S More by this author
Linseisen, J More by this author
Schlehofer, B More by this author
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Journal:
Cancer epidemiology, biomarkers and prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Volume:
20
Issue:
10
Pages:
2174-2182
Publication date:
2011-10-05
DOI:
EISSN:
1538-7755
ISSN:
1055-9965
URN:
uuid:97558eb5-0563-4a40-9214-b7ad3d13dd1b
Source identifiers:
170140
Local pid:
pubs:170140

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