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NEOSCOPE: A randomised phase II study of induction chemotherapy followed by oxaliplatin/capecitabine or carboplatin/paclitaxel based pre-operative chemoradiation for resectable oesophageal adenocarcinoma

Abstract:

Background
Oxaliplatin-capecitabine (OxCap) and carboplatin-paclitaxel (CarPac) based neo-adjuvant chemoradiotherapy (nCRT) have shown promising activity in localised, resectable oesophageal cancer.

Patients and methods
A non-blinded, randomised (1:1 via a centralised computer system), ‘pick a winner’ phase II trial. Patients with resectable oesophageal adenocarcinoma ≥ cT3 and/or ≥ cN1 were randomised to OxCapRT (oxaliplatin 85 mg/m2 day 1, 15, 29; capecitabine 625 mg/...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.ejca.2016.11.031

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology, CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
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Publisher:
Elsevier Publisher's website
Journal:
European Journal of Cancer Journal website
Volume:
74
Pages:
38–46
Publication date:
2017-02-08
Acceptance date:
2016-11-27
DOI:
ISSN:
0959-8049
Pubs id:
pubs:677367
URN:
uri:975001e0-f635-4bcb-9f97-5596b284e636
UUID:
uuid:975001e0-f635-4bcb-9f97-5596b284e636
Local pid:
pubs:677367

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