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Journal article

AMPA antagonists: do they hold more promise for clinical stroke trials than NMDA antagonists?

Abstract:

The cytoprotective effects of MK-801 and NBQX, selective N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor antagonists, respectively, were compared both singularly and in combination in models of transient severe forebrain and transient focal cerebral ischemia. After 10 minutes of four-vessel occlusion ischemia, the sodium salt of NBQX (30 mg/kg IP) given at the time of reperfusion and, subsequently, 15 and 30 minutes later produced a dr...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Stroke and Geratology
Role:
Author
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Journal:
Stroke; a journal of cerebral circulation
Volume:
24
Issue:
12 Suppl
Pages:
I148-I152
Publication date:
1993-12-05
EISSN:
1524-4628
ISSN:
0039-2499
URN:
uuid:9741943e-d589-4df6-96e5-3a2bc3be6030
Source identifiers:
80176
Local pid:
pubs:80176

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