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Journal article

Silencing of Atp2b1 increases blood pressure through vasoconstriction.

Abstract:

BACKGROUND: Recent genome-wide association studies (GWASs) have identified 30 genetic loci that regulate blood pressure, increasing our understanding of the cause of hypertension. However, it has been difficult to define the causative genes at these loci due to a lack of functional analyses. METHOD: In this study, we aimed to validate the candidate gene ATP2B1 in 12q21, variants near which have the strongest association with blood pressure in Asians and Europeans. ATP2B1 functions as a calciu...

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Publication status:
Published

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Journal:
Journal of hypertension
Volume:
31
Issue:
8
Pages:
1575-1583
Publication date:
2013-08-05
DOI:
EISSN:
1473-5598
ISSN:
0263-6352
URN:
uuid:973ff110-e899-4963-af06-0b1516558df7
Source identifiers:
401805
Local pid:
pubs:401805

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