Journal article : Review

The relationship between genome structure and function

Abstract:: Precise patterns of gene expression in metazoans are controlled by three classes of regulatory elements: promoters, enhancers and boundary elements. During differentiation and development, these elements form specific interactions in dynamic higher-order chromatin structures. However, the relationship between genome structure and its function in gene regulation is not completely understood. Here we review recent progress in this field and discuss whether genome structure plays an instructive role in regulating gene expression or is a reflection of the activity of the regulatory elements of the genome.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Oudelaar, A. M., & Higgs, D. R. (2020). The relationship between genome structure and function. Nature Reviews Genetics, 22(3), 154–168.

MLA Style

Oudelaar, AM, and DR Higgs. “The Relationship between Genome Structure and Function.” Nature Reviews Genetics, vol. 22, no. 3, 2020, pp. 154–68.

Chicago Style

Oudelaar, AM, and DR Higgs. 2020. “The Relationship between Genome Structure and Function.” Nature Reviews Genetics 22 (3): 154–68.
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Publisher copy:: 10.1038/s41576-020-00303-x

Authors

+ Oudelaar, AM More by this author

Sub department:: H5 HUMAN GENETICS WT CENTRE; H8 WEATHERALL INST OF MOLECULAR MEDICINE
Role:: Author
ORCID:: 0000-0002-4016-6158

+ Higgs, DR More by this author

Institution:: University of Oxford
Division:: MSD
Department:: RDM
Sub department:: RDM Clinical Laboratory Sciences
Role:: Author
ORCID:: 0000-0003-3579-8705

+ Medical Research Council More from this funder

Grant:: MR/T014067/1

Publisher:: Springer Nature
Journal:: Nature Reviews Genetics More from this journal
Volume:: 22
Issue:: 3
Pages:: 154-168
Place of publication:: England
Publication date:: 2020-11-24
Acceptance date:: 2020-10-21
DOI:: 10.1038/s41576-020-00303-x
EISSN:: 1471-0064
ISSN:: 1471-0056
Pmid:: 33235358

Language:: English
Keywords:: genetic

genome

gene expression regulation

chromatin

enhancer elements

promoter regions
Subtype:: Review
Pubs id:: 1146952
Local pid:: pubs:1146952
Deposit date:: 2023-11-22
ARK identifier:: ark:/29072/ora_973c324fc70c430cab07e7720331e7e5

Terms of use

Copyright holder:: Springer Nature
Copyright date:: 2021
Rights statement:: © Springer Nature Limited 2020, corrected publication 2021.
Notes:: A correction to this article is available online from Springer Nature at: https://doi.org/10.1038/s41576-020-00303-x

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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