Journal article

Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity

Abstract:: Introduction
Obesity accounts for a substantial and growing burden of disease globally. Body adiposity is highly heritable, and human genetic studies can lead to biological and therapeutic insights.
Rationale
Whole-exome sequencing of hundreds of thousands of individuals is complementary to approaches used to date in obesity genetics and has the potential to identify rare protein-coding variants with large phenotypic impact. We sequenced the ex... Expand abstract
Collapse abstract

Publication status:: Published

Peer review status:: Peer reviewed

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

-
Your message (optional)
Please add any additional information to be included within the email.
Cite

Cite this record

APA Style

Akbari, P., Gilani, A., Sosina, O., Torres, J. M., Collins, R., Emberson, J. R., & Marchini, J. (2021). Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity. Science, 373(6550).

MLA Style

Akbari, P., et al. “Sequencing of 640,000 Exomes Identifies GPR75 Variants Associated with Protection from Obesity.” Science, vol. 373, no. 6550, American Association for the Advancement of Science, 2021.

Chicago Style

Akbari, P, A Gilani, O Sosina, JM Torres, R Collins, JR Emberson, and J Marchini. 2021. “Sequencing of 640,000 Exomes Identifies GPR75 Variants Associated with Protection from Obesity.” Science 373 (6550).
Share
Print

Access Document

Files:: Akbari_et_al_2021_Sequencing_of_exomes.zip

(Accepted manuscript, 2.1MB, Terms of use)

Publisher copy:: 10.1126/science.abf8683

Authors

+ Akbari, P More by this author

Role:: Author
ORCID:: 0000-0001-9210-4760

+ Gilani, A More by this author

Role:: Author
ORCID:: 0000-0002-5100-0110

+ Sosina, O More by this author

Role:: Author
ORCID:: 0000-0003-2120-0338

+ Torres, JM More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Nuffield Department of Population Health
Sub department:: Clinical Trial Service Unit
Role:: Author

+ Collins, R More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Nuffield Department of Population Health
Sub department:: Clinical Trial Service Unit
Role:: Author

More authors...

Contributors

+ Regeneron Genetics Center

Role:: Contributor

+ DiscovEHR Collaboration

Role:: Contributor

+ NCATS NIH HHS More from this funder

Publisher:: American Association for the Advancement of Science
Journal:: Science More from this journal
Volume:: 373
Issue:: 6550
Article number:: eabf8683
Publication date:: 2021-07-02
Acceptance date:: 2021-05-17
DOI:: 10.1126/science.abf8683
EISSN:: 1095-9203
ISSN:: 0036-8075
Pmid:: 34210852

Language:: English
Keywords:: FFR
Pubs id:: 1185268
Local pid:: pubs:1185268
Deposit date:: 2021-07-09

Terms of use

Copyright holder:: Akbari et al.
Copyright date:: 2021
Rights statement:: Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Licence:: Terms and Conditions of Use for Oxford University Research Archive

Views and Downloads

About views and downloads

If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP