- Abstract:
-
Long-term potentiation (LTP), which approximates Hebb's postulate of associative learning, typically requires depolarization-dependent glutamate receptors of the NMDA (N-methyl-D-aspartate) subtype. However, in some neurons, LTP depends instead on calcium-permeable AMPA-type receptors. This is paradoxical because intracellular polyamines block such receptors during depolarization. We report that LTP at synapses on hippocampal interneurons mediating feedback inhibition is "anti-Hebbian":Itis i...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1126/science.1137450
-
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- Journal:
- Science (New York, N.Y.)
- Volume:
- 315
- Issue:
- 5816
- Pages:
- 1262-1266
- Publication date:
- 2007-03-05
- DOI:
- EISSN:
-
1095-9203
- ISSN:
-
0036-8075
- URN:
-
uuid:973302af-b504-4781-a280-4df1d2f53957
- Source identifiers:
-
185219
- Local pid:
- pubs:185219
- Language:
- English
- Keywords:
- Copyright date:
- 2007
Journal article
Anti-Hebbian long-term potentiation in the hippocampal feedback inhibitory circuit.
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