Anti-Hebbian long-term potentiation in the hippocampal feedback inhibitory circuit.

Journal article

Long-term potentiation (LTP), which approximates Hebb's postulate of associative learning, typically requires depolarization-dependent glutamate receptors of the NMDA (N-methyl-D-aspartate) subtype. However, in some neurons, LTP depends instead on calcium-permeable AMPA-type receptors. This is paradoxical because intracellular polyamines block such receptors during depolarization. We report that LTP at synapses on hippocampal interneurons mediating feedback inhibition is "anti-Hebbian":Itis induced by presynaptic activity but prevented by postsynaptic depolarization. Anti-Hebbian LTP may occur in interneurons that are silent during periods of intense pyramidal cell firing, such as sharp waves, and lead to their altered activation during theta activity.

Authors: Lamsa, K; Heeroma, J; Somogyi, P; Rusakov, D; Kullmann, D

• Publication status: Published
• Journal: Science (New York, N.Y.)
• Volume: 315
• Issue: 5816
• Pages: 1262-1266
• Publication date: 2007-03-01
• DOI: 10.1126/science.1137450
• EISSN: 1095-9203
• ISSN: 0036-8075
• Language: English
• Keywords: Receptors, AMPA; Hippocampus; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Patch-Clamp Techniques; Male; Long-Term Potentiation; Interneurons; Rats; Pyramidal Cells; Excitatory Postsynaptic Potentials; Synapses; Animals; Spermine; Electric Stimulation; Neural Inhibition; Membrane Potentials