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Anti-Hebbian long-term potentiation in the hippocampal feedback inhibitory circuit.

Abstract:

Long-term potentiation (LTP), which approximates Hebb's postulate of associative learning, typically requires depolarization-dependent glutamate receptors of the NMDA (N-methyl-D-aspartate) subtype. However, in some neurons, LTP depends instead on calcium-permeable AMPA-type receptors. This is paradoxical because intracellular polyamines block such receptors during depolarization. We report that LTP at synapses on hippocampal interneurons mediating feedback inhibition is "anti-Hebbian":Itis i...

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Publication status:
Published

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Publisher copy:
10.1126/science.1137450

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Heeroma, JH More by this author
Somogyi, P More by this author
Rusakov, DA More by this author
Kullmann, DM More by this author
Journal:
Science (New York, N.Y.)
Volume:
315
Issue:
5816
Pages:
1262-1266
Publication date:
2007-03-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:973302af-b504-4781-a280-4df1d2f53957
Source identifiers:
185219
Local pid:
pubs:185219

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