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Genetic linkage analysis to identify a gene required for the addition of phosphoethanolamine to meningococcal lipopolysaccharide.

Abstract:

Lipopolysaccharide (LPS) is important for the virulence of Neisseria meningitidis, and is the target of immune responses. We took advantage of a monoclonal antibody (Mab B5) that recognises phosphoethanolamine (PEtn) attached to the inner core of meningococcal LPS to identify genes required for the addition of PEtn to LPS. Insertional mutants that lost Mab B5 reactivity were isolated and characterised, but failed to yield genes directly responsible for PEtn substitution. Subsequent genetic li...

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Publication status:
Published

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Authors


Mackinnon, F More by this author
Makepeace, K More by this author
Plested, J More by this author
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Journal:
Gene
Volume:
284
Issue:
1-2
Pages:
133-140
Publication date:
2002-02-05
DOI:
EISSN:
1879-0038
ISSN:
0378-1119
URN:
uuid:97280c8c-cda0-4d9a-9750-4b9ce4d421b1
Source identifiers:
246394
Local pid:
pubs:246394

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