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NON-PROTEINOGENIC AMINO-ACID SYNTHESIS - THE BETA-ANION DERIVED FROM ASPARTIC-ACID, AND ITS APPLICATION TO ALPHA-AMINO-ACID SYNTHESIS

Abstract:
Treatment of α-t-Butyl β-methyl N-Z-(S)-aspartate (2) with lithium amide bases generates the corresponding β-ester enolate, which can be alkylated with suitable electrophiles. The application of this strategy for synthesis of optically active amino acids has been investigated. © 1989.
Publication status:
Published

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Publisher copy:
10.1016/S0040-4020(01)85140-1

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Journal:
TETRAHEDRON More from this journal
Volume:
45
Issue:
19
Pages:
6309-6318
Publication date:
1989-01-01
DOI:
ISSN:
0040-4020


Language:
English
Keywords:
Pubs id:
pubs:43165
UUID:
uuid:97061087-7221-4be2-9c96-73d84b02f819
Local pid:
pubs:43165
Source identifiers:
43165
Deposit date:
2012-12-19

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