Inwardly rectifying potassium channels (K<sub>IR</sub>) in GtoPdb v.2025.4

Journal article

The 2TM domain family of K channels are also known as the inward-rectifier K channel family. This family includes the strong inward-rectifier K channels (Kir2.x) that are constitutively active, the G protein-activated inward-rectifier K channels (Kir3.x) and the ATP-sensitive K channels (Kir6.x, which combine with sulphonylurea receptors (SUR1-3)). The pore-forming α subunits form tetramers, and heteromeric channels may be formed within subfamilies (e.g. Kir3.2 with Kir3.3).

Authors: Adelman, JP; Tucker, S; Slesinger, PA; Seino, S; Sackin, H

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Edinburgh University Library
• Journal: IUPHAR/BPS Guide to Pharmacology CITE
• Volume: 2025
• Issue: 4
• Publication date: 2025-12-10
• DOI: 10.2218/gtopdb/f74/2025.4
• EISSN: 2633-1020
• ISSN: 2633-1020
• Language: English
• Keywords: SK channel; Calcium-activated potassium channel; Ion channel; Potassium channel; Light-gated ion channel; Ligand-gated ion channel; Inward-rectifier potassium ion channel; Cardiac action potential; Channel (broadcasting)