Transcriptional termination in mammals: Stopping the RNA polymerase II juggernaut.
Terminating transcription is a highly intricate process for mammalian protein-coding genes. First, the chromatin template slows down transcription at the gene end. Then, the transcript is cleaved at the poly(A) signal to release the messenger RNA.The remaining transcript is selectively unraveled and degraded.This induces critical conformational changes in the heart of the enzyme that trigger termination. Termination can also occur at variable positions along the gene and so prevent aberrant t...Expand abstract
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