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Transcriptional termination in mammals: Stopping the RNA polymerase II juggernaut.

Abstract:

Terminating transcription is a highly intricate process for mammalian protein-coding genes. First, the chromatin template slows down transcription at the gene end. Then, the transcript is cleaved at the poly(A) signal to release the messenger RNA.The remaining transcript is selectively unraveled and degraded.This induces critical conformational changes in the heart of the enzyme that trigger termination. Termination can also occur at variable positions along the gene and so prevent aberrant t...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1126/science.aad9926

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Journal website
Volume:
352
Issue:
6291
Pages:
aad9926
Publication date:
2016-06-05
Acceptance date:
2016-06-09
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:96e0eccd-d0c1-4d8e-85a8-b52788059fa1
Source identifiers:
628360
Local pid:
pubs:628360

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