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Journal article

Expression of murine IL-12 is regulated by translational control of the p35 subunit.

Abstract:

IL-12 is a heterodimer of two subunits, p35 and p40, encoded by separate genes that are regulated independently. To investigate the mechanisms underlying the regulation of the p35 gene, we characterized murine p35 expression in the B cell lymphoma line A20 and in bone marrow-derived dendritic cells. Multiple transcription start sites were identified in both cell types, resulting in four p35 mRNA isoforms (types I-IV) that differ in the number and position of upstream ATGs in their 5' untransl...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
162
Issue:
7
Pages:
4069-4078
Publication date:
1999-04-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:96dab7fb-802d-4c30-829d-383448e7843b
Source identifiers:
18601
Local pid:
pubs:18601

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