Expression of murine IL-12 is regulated by translational control of the p35 subunit.

Babik, JM; Adams, E; Tone, Y; Fairchild, PJ; Tone, M; Waldmann, H

Abstract:

IL-12 is a heterodimer of two subunits, p35 and p40, encoded by separate genes that are regulated independently. To investigate the mechanisms underlying the regulation of the p35 gene, we characterized murine p35 expression in the B cell lymphoma line A20 and in bone marrow-derived dendritic cells. Multiple transcription start sites were identified in both cell types, resulting in four p35 mRNA isoforms (types I-IV) that differ in the number and position of upstream ATGs in their 5' untransl...

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APA Style

Babik, J. M., Adams, E., Tone, Y., Fairchild, P. J., Tone, M., & Waldmann, H. (1999). Expression of murine IL-12 is regulated by translational control of the p35 subunit. Journal of Immunology (Baltimore, Md. : 1950), 162(7), 4069–4078.

MLA Style

Babik, J. M., et al. “Expression of Murine IL-12 Is Regulated by Translational Control of the p35 Subunit.” Journal of Immunology (Baltimore, Md. : 1950), vol. 162, no. 7, 1999, pp. 4069–78.

Chicago Style

Babik, JM, E Adams, Y Tone, PJ Fairchild, M Tone, and H Waldmann. 1999. “Expression of Murine IL-12 Is Regulated by Translational Control of the p35 Subunit.” Journal of Immunology (Baltimore, Md. : 1950) 162 (7): 4069–78.
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