Positron emission tomography: a real-time tool to quantify early islet engraftment in a preclinical large animal model.
BACKGROUND: Clinical islet transplantation is currently being explored as a therapeutic option for persons with type I diabetes and hypoglycemic unawareness. Techniques to monitor graft survival are urgently needed to optimize the procedure. Therefore, the objective of the present study was to develop a technique for imaging survival of transplanted islets in the peritransplant and early posttransplant phase. METHODS: Isolated porcine islets were labeled in vitro with 2-deoxy-2[F]fluoro-D-gl...Expand abstract
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