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Positron emission tomography: a real-time tool to quantify early islet engraftment in a preclinical large animal model.

Abstract:

BACKGROUND: Clinical islet transplantation is currently being explored as a therapeutic option for persons with type I diabetes and hypoglycemic unawareness. Techniques to monitor graft survival are urgently needed to optimize the procedure. Therefore, the objective of the present study was to develop a technique for imaging survival of transplanted islets in the peritransplant and early posttransplant phase. METHODS: Isolated porcine islets were labeled in vitro with 2-deoxy-2[F]fluoro-D-gl...

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Authors


Eriksson, O More by this author
Estrada, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
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Journal:
Transplantation
Volume:
84
Issue:
7
Pages:
893-898
Publication date:
2007-10-05
DOI:
EISSN:
1534-6080
ISSN:
0041-1337
URN:
uuid:96be4f61-f90b-4a95-9297-db59527b117b
Source identifiers:
272792
Local pid:
pubs:272792

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