Journal article

Convergence of longevity and immunity: lessons from animal models

Abstract:: An increasing amount of data implicate immunity-mostly innate immunity-in the ageing process; both during healthy ageing as well as in neurodegenerative diseases. Despite the aetiology however, the underlying mechanisms are poorly understood. Here we review what we know from model organisms (worms, flies and mice) on the possible mechanistic details that connect immunity and ageing. These links provide evidence that inter-tissue communication (especially the interaction between gut and brain), hormonal control mechanisms and intestinal microbiota determine immune system activity and thus influence lifespan.

Publication status:: Published

Peer review status:: Peer reviewed

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

-
Your message (optional)
Please add any additional information to be included within the email.
Cite

Cite this record

APA Style

Xia, J., Gravato-Nobre, M., & Ligoxygakis, P. (2019). Convergence of longevity and immunity: lessons from animal models. Biogerontology, 20(3), 271–278.

MLA Style

Xia, J., et al. “Convergence of Longevity and Immunity: Lessons from Animal Models.” Biogerontology, vol. 20, no. 3, Springer Nature, 2019, pp. 271–78.

Chicago Style

Xia, J, M Gravato-Nobre, and P Ligoxygakis. 2019. “Convergence of Longevity and Immunity: Lessons from Animal Models.” Biogerontology 20 (3): 271–78.
Share
Print

Access Document

Files:: Xia2019_Biogerontology.pdf

(Preview, Version of record, pdf, 356.9KB, Terms of use)

Publisher copy:: 10.1007/s10522-019-09801-w

Authors

+ Xia, J More by this author

Institution:: University of Oxford
Division:: Medical Sciences Division
Department:: Biochemistry
Role:: Author

+ Gravato-Nobre, M More by this author

Institution:: University of Oxford
Division:: Medical Sciences Division
Department:: Biochemistry
Role:: Author

+ Ligoxygakis, P More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Biochemistry
Oxford college:: St Cross College
Role:: Author

Publisher:: Springer Nature
Journal:: Biogerontology More from this journal
Volume:: 20
Issue:: 3
Pages:: 271-278
Publication date:: 2019-02-22
Acceptance date:: 2019-02-07
DOI:: 10.1007/s10522-019-09801-w
EISSN:: 1573-6768
ISSN:: 1389-5729

Language:: English
Keywords:: ageing

gut

brain

model organisms

immunity

microbiome
Pubs id:: pubs:976795
UUID:: uuid:96bc57ee-6457-42c3-b4cd-ea7a236d3617
Local pid:: pubs:976795
Source identifiers:: 976795
Deposit date:: 2019-02-27

Terms of use

Copyright holder:: Xia et al
Copyright date:: 2019
Notes:: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original authors and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Licence:: CC Attribution (CC BY)

Views and Downloads

About views and downloads

If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP