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Journal article

Primary, post-primary and non-specific immunoglobulin M responses in HCV infection.

Abstract:

Delayed and variable antibody responses to HCV make it difficult to diagnose acute HCV infection reliably. Immunoglobulin (Ig)M and IgG anti-HCV may be observed simultaneously as disease persists. IgM plays a key role in mixed cryoglobulinemia (MC), an immune complex disease strongly associated with persistent HCV infection. In MC, clonal or oligoclonal IgM rheumatoid factors facilitate the deposition of immune complexes in small blood vessels and tissue, leading to inflammation, complement a...

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Publisher copy:
10.3851/imp2222

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Antiviral therapy
Volume:
17
Issue:
7 Pt B
Pages:
1449-1452
Publication date:
2012-01-01
DOI:
EISSN:
2040-2058
ISSN:
1359-6535
URN:
uuid:969ee417-841d-48fc-8587-49238ae7c5aa
Source identifiers:
426214
Local pid:
pubs:426214

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