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Journal article

Potential for immune-driven viral polymorphisms to compromise antiretroviral-based preexposure prophylaxis for prevention of HIV-1 infection

Abstract:

Objective

Long-acting rilpivirine is a candidate for pre-exposure prophylaxis (PrEP) for prevention of HIV-1 infection. However, rilpivirine resistance mutations at reverse transcriptase codon 138 (RT-E138X) occur naturally in a minority of HIV-1-infected persons; in particular those expressing Human Leukocyte Antigen (HLA)-B*18 where RT-E138X arises as an immune escape mutation. We investigate the global prevalence, B*18-linkage and replicative cost of RT-E138X and its regional ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1097/qad.0000000000001575

Authors


Gatanaga, H More by this author
Brumme, ZL More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
Reyes-Terán, G More by this author
Avila-Rios, S More by this author
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Japan Agency for Medical Research and Development More from this funder
Canadian Institutes for Health Research More from this funder
Michael Smith Foundation for Health Research More from this funder
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Publisher:
Lippincott, Williams & Wilkins Publisher's website
Journal:
AIDS Journal website
Volume:
31
Issue:
14
Pages:
1935-1943
Publication date:
2017-09-10
Acceptance date:
2017-06-09
DOI:
EISSN:
1473-5571
ISSN:
0269-9370
Pubs id:
pubs:702338
URN:
uri:968e6b2a-b351-4981-adc4-b073e3bf22a1
UUID:
uuid:968e6b2a-b351-4981-adc4-b073e3bf22a1
Local pid:
pubs:702338

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