Journal article
Ultrasound-triggered delivery of iproplatin from microbubble-conjugated liposomes
- Abstract:
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The PtIV prodrug iproplatin has been actively loaded into liposomes using a calcium acetate gradient, achieving a 3-fold enhancement in drug concentration compared to passive loading strategies. A strain-promoted cycloaddition reaction (azide- dibenzocyclooctyne) was used to attach iproplatin-loaded liposomes L(Pt) to gas-filled microbubbles (M), forming an ultrasound-responsive drug delivery vehicle [M−L(Pt)]. Ultrasound-triggered release of iproplatin from the microbubble-liposome construct was evaluated in cellulo. Breast cancer (MCF-7) cells treated with both free iproplatin and iproplatin-loaded liposome−microbubbles [M−L(Pt)] demonstrated an increase in platinum concentration when exposed to ultrasound. No appreciable platinum uptake was observed in MCF-7 cells following treatment with L(Pt) only or L(Pt)+ultrasound, suggesting that microbubble-mediated ultrasonic release of platinum-based drugs from liposomal carriers enables greater control over drug delivery.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 1.8MB, Terms of use)
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- Publisher copy:
- 10.1002/open.202100222
Authors
- Grant:
- EP/L024012/1
- EP/I021795/1
- Publisher:
- Wiley
- Journal:
- ChemistryOpen More from this journal
- Volume:
- 10
- Issue:
- 12
- Pages:
- 1170-1176
- Publication date:
- 2021-10-27
- Acceptance date:
- 2021-10-06
- DOI:
- EISSN:
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2191-1363
- Pmid:
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34708552
- Language:
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English
- Keywords:
- Pubs id:
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1209006
- Local pid:
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pubs:1209006
- Deposit date:
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2022-08-19
Terms of use
- Copyright holder:
- Browning et al.
- Copyright date:
- 2021
- Rights statement:
- © 2021 The Authors. Published by Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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