Journal article
Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis.
- Abstract:
-
Breakdown of triple-helical interstitial collagens is essential in embryonic development, organ morphogenesis and tissue remodelling and repair. Aberrant collagenolysis may result in diseases such as arthritis, cancer, atherosclerosis, aneurysm and fibrosis. In vertebrates, it is initiated by collagenases belonging to the matrix metalloproteinase (MMP) family. The three-dimensional structure of a prototypic collagenase, MMP-1, indicates that the substrate-binding site of the enzyme is too nar...
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- Publication status:
- Published
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- Publisher copy:
- 10.1038/sj.emboj.7600318
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Authors
Bibliographic Details
- Journal:
- EMBO journal
- Volume:
- 23
- Issue:
- 15
- Pages:
- 3020-3030
- Publication date:
- 2004-08-01
- DOI:
- EISSN:
-
1460-2075
- ISSN:
-
0261-4189
- Source identifiers:
-
227333
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:227333
- UUID:
-
uuid:966e0105-4a4f-4396-b318-4d07e48435dd
- Local pid:
- pubs:227333
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2004
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