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Journal article

Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis.

Abstract:

Breakdown of triple-helical interstitial collagens is essential in embryonic development, organ morphogenesis and tissue remodelling and repair. Aberrant collagenolysis may result in diseases such as arthritis, cancer, atherosclerosis, aneurysm and fibrosis. In vertebrates, it is initiated by collagenases belonging to the matrix metalloproteinase (MMP) family. The three-dimensional structure of a prototypic collagenase, MMP-1, indicates that the substrate-binding site of the enzyme is too nar...

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Publication status:
Published

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Publisher copy:
10.1038/sj.emboj.7600318

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Journal:
The EMBO journal
Volume:
23
Issue:
15
Pages:
3020-3030
Publication date:
2004-08-05
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:966e0105-4a4f-4396-b318-4d07e48435dd
Source identifiers:
227333
Local pid:
pubs:227333

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