- Abstract:
-
Breakdown of triple-helical interstitial collagens is essential in embryonic development, organ morphogenesis and tissue remodelling and repair. Aberrant collagenolysis may result in diseases such as arthritis, cancer, atherosclerosis, aneurysm and fibrosis. In vertebrates, it is initiated by collagenases belonging to the matrix metalloproteinase (MMP) family. The three-dimensional structure of a prototypic collagenase, MMP-1, indicates that the substrate-binding site of the enzyme is too nar...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/sj.emboj.7600318
-
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- Journal:
- The EMBO journal
- Volume:
- 23
- Issue:
- 15
- Pages:
- 3020-3030
- Publication date:
- 2004-08-05
- DOI:
- EISSN:
-
1460-2075
- ISSN:
-
0261-4189
- URN:
-
uuid:966e0105-4a4f-4396-b318-4d07e48435dd
- Source identifiers:
-
227333
- Local pid:
- pubs:227333
- Copyright date:
- 2004
Journal article
Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis.
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