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Diversity-oriented approach to CF3CHF-, CF3CFBr-, CF3CF2-, (CF3)2CH-, and CF3(SCF3)CH-substituted arenes from 1-(diazo-2,2,2-trifluoroethyl)arenes.

Abstract:

Arenes substituted with perfluoroalkyl groups are attractive targets for drug and agrochemical development. Exploiting the carbenic character of donor/acceptor diazo compounds, a diversity-oriented synthesis of perfluoroalkylated arenes, for late stage fluorofunctionalization, is described. The reaction of 1-(diazo-2,2,2-trifluoroethyl)arenes with HF, F/Br, F2, CF3H, and CF3SH sources give direct access to a variety of perfluoroalkyl-substituted arenes presenting with incremental fluorine con...

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Publication status:
Published

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Publisher copy:
10.1021/ol5030184

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Publisher:
American Chemical Society
Journal:
Organic letters
Volume:
16
Issue:
22
Pages:
6004-6007
Publication date:
2014-11-05
DOI:
EISSN:
1523-7052
ISSN:
1523-7060
URN:
uuid:965bac08-0574-4881-868d-65c3f3e17b5f
Source identifiers:
489778
Local pid:
pubs:489778
Language:
English

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