Journal article
Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation
- Abstract:
- Most mammalian protein coding genes are subject to alternative cleavage and polyadenylation (APA), which can generate distinct mRNA 3'UTRs with differing regulatory potential. Although this process has been intensely studied in recent years, it remains unclear how and to what extent cleavage site selection is regulated under different physiological conditions. The cleavage factor Im (CFIm) complex is a core component of the mammalian cleavage machinery, and the observation that its depletion causes transcriptome-wide changes in cleavage site use makes it a key candidate regulator of APA. This review aims to summarize current knowledge of the CFIm complex, and explores the evidence surrounding its potential contribution to regulation of APA.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
-
-
(Preview, Accepted manuscript, pdf, 206.9KB, Terms of use)
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- Publisher copy:
- 10.1042/BST20160078
Authors
- Publisher:
- Portland Press
- Journal:
- Biochemical Society transactions More from this journal
- Volume:
- 44
- Issue:
- 4
- Pages:
- 1051-1057
- Publication date:
- 2016-09-15
- Acceptance date:
- 2016-05-11
- DOI:
- EISSN:
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1470-8752
- ISSN:
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0300-5127
- Pmid:
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27528751
- Language:
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English
- Keywords:
- Pubs id:
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pubs:640618
- UUID:
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uuid:964ad012-7b51-4a2a-b283-2a8d5f9002c3
- Local pid:
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pubs:640618
- Source identifiers:
-
640618
- Deposit date:
-
2016-09-26
Terms of use
- Copyright holder:
- © Hardy & Norbury
- Copyright date:
- 2016
- Notes:
- © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society. This is the author accepted manuscript following peer review version of the article. The final version is available online from Portland Press Limted at: 10.1042/BST20160078
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