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Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation

Abstract:

Most mammalian protein coding genes are subject to alternative cleavage and polyadenylation (APA), which can generate distinct mRNA 3'UTRs with differing regulatory potential. Although this process has been intensely studied in recent years, it remains unclear how and to what extent cleavage site selection is regulated under different physiological conditions. The cleavage factor Im (CFIm) complex is a core component of the mammalian cleavage machinery, and the observation that its depletion ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1042/BST20160078

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Department:
Oxford, MSD, Pathology Dunn School
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Department:
Oxford, MSD, Pathology Dunn School
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Grant:
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Publisher:
Portland Press Publisher's website
Journal:
Biochemical Society transactions Journal website
Volume:
44
Issue:
4
Pages:
1051-1057
Publication date:
2016-09-15
Acceptance date:
2016-05-11
DOI:
EISSN:
1470-8752
ISSN:
0300-5127
Pubs id:
pubs:640618
URN:
uri:964ad012-7b51-4a2a-b283-2a8d5f9002c3
UUID:
uuid:964ad012-7b51-4a2a-b283-2a8d5f9002c3
Local pid:
pubs:640618

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