Can exercise training enhance the repeated remote ischaemic preconditioning stimulus on peripheral and cerebrovascular function in high-risk individuals?

Journal article

BACKGROUND: Repeated exposure to remote ischaemic preconditioning (rIPC; short bouts of non-lethal ischaemia) enhances peripheral vascular function within 1 week; whereas, longer periods of rIPC (~ 1 year) may improve cerebral perfusion. Increasing the 'dose' of rIPC may lead to superior effects. Given the similarities between exercise and rIPC, we examined whether adding exercise to the rIPC stimulus leads to greater adaptation in systemic vascular function. METHODS: ) using a maximal aerobic capacity test. RESULTS: increased by 2.8 ml/kg/min (1.7, 3.9) following the rIPC + Ex and by 0.1 ml/kg/min (- 1.0, 1.4) following the rIPC only intervention (P = 0.69). CONCLUSION: Combining exercise with rIPC across an 8-week intervention does not lead to superior effects in cerebrovascular and peripheral vascular function compared to a repeated rIPC intervention in individuals at risk of CVD.

Authors: Maxwell, JD; France, M; Finnigan, LEM; Carter, HH; Thijssen, DHJ

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Springer
• Journal: European Journal of Applied Physiology
• Volume: 121
• Issue: 4
• Pages: 1167-1178
• Publication date: 2021-01-28
• DOI: 10.1007/s00421-020-04580-6
• EISSN: 1439-6327
• ISSN: 1439-6319
• Language: English
• Keywords: Cardiology; Peripheral; Blood pressure; Internal medicine; VO2 max; Heart rate; Medicine; Ischemia; Anesthesia; Ischemic preconditioning